ctss breaks up proteins into small pieces that may be used to degrade parts of a pathogen. This includes disease causing bacteria, virus, or protozoan into small peptides. A Major Histocompatibility Complex (MHC) class II recognizes these peptides and signals for the immune response to take place.

The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction The levels of cathepsin S were associated with the degree of airflow limitation and emphysema phenotype in COPD [chronic obstructive pulmonary disease].

CTSS (uc010pcj.2) at chr1:150702672-150738433 - Homo sapiens cathepsin S (CTSS), transcript variant 2, mRNA. This gene is involved in the proteolysis of antigenic proteins. You are currently offline. Some features of the site may not work correctly. Because this designation had been used for a different gene (see 600550), the official name of the gene identified by Shi et al.

Recently, type 1 IFN-mediated activation of lysosomes and lysosomal cathepsins (CTSs) Mar 4, 2021 Targeting the enzymatic activity of cathepsin S (CTSS) by pharmacological blockade and gene deficiency strategy alleviates the manifestations and CtsL−/− but not CtsC−/− or CtsS−/− RT2 mice. Given the substantial differences observed in tumor vol- ume between the four cathepsin knockouts, we Imports a "CTSS" file in a GPos object. CTSS. In CAGEr: Analysis of CAGE ( Cap Analysis of Gene Expression) sequencing data for precise mapping of Jun 6, 2019 Results: Among 12 genes with ratios higher than that of a housekeeping gene, we selected CTSS for scrutinizing protein expression in serum Jun 25, 2018 4.2.1 CTSS data; 4.2.2 Cluster data; 4.2.3 Gene data. 4.3 Summary of the CAGEexp experiment slots and assays. 4.3.1 CAGEexp assays. Assay details for Ctss, CPTAC-3897.

Gene Ontology (GO) annotations related to this gene include identical protein binding and cysteine-type peptidase activity. K01368 CTSS; cathepsin S 09182 Protein families: genetic information processing 03110 Chaperones and folding catalysts K01368 CTSS; cathepsin S Enzymes [BR:ko01000] 3.

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Dacryoadenitis and Cerebellopontine Angle Tumor . Among its related pathways are Bacterial infections in CF airways and Degradation of the extracellular matrix .

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation.

utvärderades med 260/280 UV-absorptionsförhållanden (Gene Quant 1300, Våra resultat visar att mRNA-nivåerna för NF-KB, CRP, CST3, CTSS, MMP 2,

Human FL Biopsy Samples with CTSS Y132 Mutations. Have Gene Expression Profiles Linked with Antigen. Processing and Apr 10, 2018 Cathepsin S (CTSS) and Sirtuin-1 (SIRT1) played crucial roles in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported.
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This gene is involved in the proteolysis of antigenic proteins. You are currently offline. Some features of the site may not work correctly. Because this designation had been used for a different gene (see 600550), the official name of the gene identified by Shi et al.

Official gene symbol, … Summary of CTSS expression in human tissue. Cytoplasmic expression in most tissues, highly abundant in subsets of immune cells. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.
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Conclusion: The single nucleotide polymorphisms (SNPs) of rs774320676 and rs928508030 of CTSS gene were related with risk for acute atherosclerotic cerebral infarction. The T allele at rs774320676 locus and G allele at rs928508030 locus of CTSS were genetic susceptibility genes of acute atherosclerotic cerebral infarction.

These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Ctss Gene Detail Summary Symbol. Ctss Name.

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Mar 1, 2000 We found a novel G → A change at nucleotide −25 within the promoter of the CTSS gene encoding the elastase cathepsin S. The

Cat S. Location This gene has proteins that correspond to the following Uniprot identifiers: P30279. May 12, 2020 CTSS production, activation, and secretion. The Ctss gene is found at the 1q21 chromosome in humans and, like all lysosomal cathepsins, is Using the breast cancer dataset, survival dependent on CTSS gene expression was analysed based on intrinsic patient subtype, using a collation of previously CTSS (cathepsin S) · Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute Jan 29, 2020 Gene expression of Ctss, together with the pro-inflammatory cytokines, Ifng and Tnf, were significantly elevated in NOD mouse LG (Fig.